THD Fleben® Line: flavonoid supplements - THDLAB - COM

  • Chronic venous insufficiency and haemorrhoidal disease
  • THD Fleben® and THD Fleben® 1000: indications
  • THD Fleben® and THD Fleben® 1000: features and mode of action
  • THD Fleben® and THD Fleben® 1000: nutritional information and dosage

Chronic venous insufficiency and haemorrhoidal disease

The term "chronic venous insufficiency" (CVI) indicates a set of clinical manifestations with high incidence, characterised by functional anomalies of the venous system. Lower limb oedema and haemorrhoidal disease are some of the main manifestations of CVI.

In haemorrhoidal disease, the alteration of the venous microcirculation occurs at the level of the haemorrhoidal plexus. Insufficient venous drainage causes blood to stagnate at the level of the haemorrhoidal cushions. Blood stasis triggers inflammatory processes at local level, favouring the onset of oedema, irritation, bleeding and the progressive weakening of the peripheral venous vessels.

Venous insufficiency can be subsequent to the degeneration of the connective tissue supporting the haemorrhoidal plexus or arise from the increase in pre-capillary arterial flow. In any case, CVI is one of the main elements on which it is necessary to act in the presence of symptomatic haemorrhoids, where inflammation and the weakness of peripheral venous vessels are the key elements.

The administration of products based on phlebotonic or vein-protective substances is a central element of haemorrhoidal disease therapy, particularly in the early stages of the disease. In the initial stages of haemorrhoids, use of these products can in fact slow down and prevent the progression of the disease. In this case, prevention has a double meaning: to prevent and delay the onset of the disease and if the latter is already present, to reduce and delay its deterioration.

THD research has created the THD Fleben® Line, the line of bioflavonoid supplements dedicated to the health and well-being of venous microcirculation


  • L’insufficienza venosa cronica: risultati di un’indagine epidemiologica in Italia., P.L. Antignani, A. Vestri, C. Allegra, Il Quaderno della Flebologia, 2015. Studio sull’epidemiologia e prevalenza delle Flebopatie Croniche della Società Italiana di Angiologia e Patologia Vascolare - SIAVAP

THD Fleben® and THD Fleben® 1000: indications

THD Fleben® and THD Fleben® 1000 are bioflavonoid supplements useful in case of increased need of the components they contain and with beneficial effects on the venous microcirculation.

THD Fleben® is a dietary supplement based on Diosmin and standardised extract of Melilotus, indicated in case of an increased need of the components.

THD Fleben® 1000 is a supplement with a high flavonoid content, adjuvant in the treatment of microcirculation problems.

THD Fleben® 1000 is a product with a complete and energetic action, thanks to the high content of various Flavonoids, while THD Fleben® is particularly useful for subsequent maintenance.


THD Fleben® and THD Fleben® 1000: features and mode of action

The mix of substances contained in THD Fleben® and THD Fleben® 1000 can be a useful support, in case of:

  • oedema and venous stasis.
  • problems in lymphatic and venous return circulation.

THD Fleben® contains a special association of substances of plant origin which favours the physiological well-being of the microcirculation.

THD Fleben® 1000 has an innovative composition in terms of variety and concentration of the components.

Thanks to the 4 different flavonoids it contains and to their high concentration (1000 mg), THD Fleben® 1000 is a useful aid when there is a weakening of the venous vessels and the relative inflammatory conditions, key factors of microcirculatory problems.

THD Fleben® 1000 offers further advantages:

  • high bioflavonoid content
  • ready to use
  • simple daily dosage and easy to take
  • sweetened with fructose
  • gluten-free
  • lactose-free


  • Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I–III degree hemorroidal disease: a double-blind multicenter prospective comparative study, Corsale I., Carrieri P. et al., International Journal of Colorectal Disease, November 2018, Volume 33, Issue 11, pp 1595–1600
  • Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial, Altomare D.F. et al, Tech Coloproctol. 2015 Jun; 19(6): 339-45

THD Fleben® and THD Fleben® 1000: nutritional information and dosage

THD Fleben® Line

What it looks like: THD Fleben® is sold in tablets.

Recommended dosage: we recommend taking 1 tablet a day, preferably between meals. Drink plenty of water for best results.

Ingredients: Diosmin, Bulking Agent: Dicalcium phosphate, yellow sweet clover (Melilotus officinalis (L.) Pall., Maltodextrin) herba cum floribus dry extract titrated 20% coumarins, coating agents: Polyvinyl alcohol, polyethylene glycol, polysorbate 80; Anti-caking agents: Cross-linked carboxymethyl cellulose sodium, Silicon dioxide, Magnesium salts of fatty acids, Talc; Dyes: E132, E171, E172.

THD Fleben® can be purchased in all pharmacies and drug stores.

THD Fleben® 1000

What it looks like: THD Fleben® 1000 is sold in single-dose vials.

Recommended dosage: the recommended dose is one vial a day. Shake well before use.

Ingredients: water, fructose, vegetable glycerine, Rutin, Quercetin, Diosmin, Hesperidin, flavours, stabilizers: polysorbate 80, sucrose esters; preservative: potassium sorbate; acidifying agent: citric acid; thickener: xanthan gum; sweetener: sucralose.

THD Fleben® 1000 can be purchased in all pharmacies and drug stores.

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